5. The use of long-acting insulin analogues during the initiation of insulin therapy Gao Hongjiao, Department of Endocrinology, Zunyi First People’s Hospital (1). When only basal insulin therapy is used, it is not necessary to discontinue insulin pro-secretory agents. (2). Usage: Continue oral hypoglycemic therapy, combined with long-acting insulin analogues injected at bedtime. The starting dose is 0.2 U/(kg-d), i.e. if the patient weighs 60 Kg, the starting amount is 12 U. Adjust the insulin dosage according to the patient’s fasting blood glucose level, usually every 3 to 5 days, and adjust 1 to 4 U each time according to the level of blood glucose until the fasting blood glucose standard is reached. (3). If fasting glucose control is satisfactory after 3 months but glycosylated hemoglobin (HbA1c) does not reach the standard, adjustment of insulin treatment plan should be considered. 6. Combined use of long-acting insulin analogues and oral hypoglycemic agents (1). For patients with type 2 diabetes, especially obese type 2 diabetes, metformin is still the basic drug. (2). Since both long-acting insulin analogs and metformin focus on lowering basal blood glucose, the combination of α-glucosidase inhibitors or glinides is the superior choice, because the latter two are drugs that lower postprandial blood glucose. α-glucosidase inhibitors (acarbose, voglibose) are more suitable for diabetic patients who prefer pasta, while glinides (repaglinide, miglinide, nateglinide) are not suitable for patients with poor pancreatic beta function. poorer diabetic patients. In other words, a good glucose-lowering program must be personalized after understanding the patient’s age, body type, liver and kidney function, lifestyle habits and their pancreatic beta function. Confucius taught “teach according to your ability”, and so does the doctor’s treatment of diabetic patients. The above content is from the WeChat subscription number “Zunyi Diabetes Education Window”. You can join by searching for the micro signal “zytnbw” in the WeChat “Add Friend”, or you can directly “sweep” the above WeChat QR code to join.