Diabetic patients will have some peripheral vascular lesions due to long-term hyperglycemia, and at the same time, they will combine with peripheral neuropathy, so when the peripheral blood vessels and the peripheral skin breaks down, due to poor glycemic control, it will lead to this situation is not easy to heal. So when there is a lower limb rupture, it is necessary to take a local culture of the secretion, and at the same time to control the patient’s blood sugar in an appropriate range. Insulin is usually used to control blood glucose, because in addition to controlling the patient’s blood glucose quickly, it also has the effect of promoting tissue healing. The patient is treated with local debridement and given treatments to improve circulation in the lower extremities, anti-oxidative stress, and nerve nutrition. Then there is a need to apply antibiotics, at the beginning if the results of drug sensitivity is not out, may be based on clinical experience to choose antibiotic treatment, if the results of drug sensitivity is out, need to be based on the results of drug sensitivity culture, choose targeted antibacterial drug treatment.