Sternal tubercle pain may be caused by trauma, angina pectoris, costochondritis, mediastinal tumor and so on. 1. Trauma: the sternum handle is violently impacted, extrusion and other traumatic injuries lead to sternum handle fracture, skin bruising and edema, which leads to pain at the sternum handle. 2. Angina pectoris: coronary atherosclerosis leads to narrowing of the lumen, which induces myocardial ischemia under the stimulation of emotional excitement and strenuous exercise, resulting in pain in the anterior region of the heart, which may involve the sternal handle. 3. Costal chondritis: the cartilage tissue at the junction of sternum and ribs is inflamed due to infection, trauma and other factors, resulting in pain at the sternal handle. 5. Mediastinal tumor: Thymoma, teratoma, retrosternal thyroid tumor and other diseases cause compression of the sternal styloid, resulting in pain at the sternal styloid. The pain at the sternal handle may be related to many factors, it is recommended to go to the hospital in time, after clarifying the cause of the disease, symptomatic treatment, to avoid delaying the condition.