Multiple joint pain can be caused by the following reasons: first, rheumatism and rheumatoid, rheumatism and rheumatoid can involve multiple joints, rheumatoid often involves small joints in the hands and feet, while rheumatism can involve large and small joints, often accompanied by wandering pain, with symptoms of increased pain and morning stiffness when waking up, then we should take early joint x-ray and blood tests for early diagnosis and early treatment. Second, gout, gout can involve many joints in the human body, there can be pain, swelling and skin redness, skin temperature increased, and in serious cases, there will be gout stone formation, it is necessary to check the blood uric acid early for early diagnosis and early treatment. Third, large osteoarthrosis, large osteoarthrosis can involve multiple joints in the human body, especially the hands and feet and knee and ankle joints are more significant, it is necessary to combine the patient’s growth environment and joint x-ray to early diagnosis. Fourth, ankylosing spondylitis, part of the ankylosing spondylitis patients can also appear multiple joint pain.