1.Replacement therapy: For acute and chronic adrenocortical insufficiency, hypopituitarism and supplementary replacement therapy after subtotal adrenalectomy. 2.Severe acute infection or inflammation. (1) Severe acute infection, for bacterial severe acute infection in the application of adequate amounts of effective antibacterial drugs at the same time. With GCS, using its anti-inflammatory and anti-toxic effects, it can relieve symptoms and help patients to pass the dangerous period. For viral infections, GCS is generally not used and can be exacerbated in patients with varicella and herpes zoster. However, for patients with severe hepatitis, mumps, measles and BSE, the symptoms can be relieved after use. 2) Prevent inflammatory sequelae, for meningitis, pericarditis, arthritis and burns, etc. GCS can reduce scars and adhesions and reduce the sequelae of inflammation. For iritis, keratitis, retinitis, in addition to the above-mentioned effects, it can also produce anti-inflammatory and pain-relieving effects. (3) Autoimmune and allergic diseases (1) Autoimmune diseases: GCS can relieve the symptoms of rheumatic fever, rheumatoid arthritis, systemic lupus erythematosus and other autoimmune diseases. It can inhibit the rejection reaction when applied after organ transplantation. (2) Allergic diseases: GCS can relieve symptoms of urticaria, kwashiorkor fever, allergic rhinitis and other allergic diseases. However, it cannot cure. 4.Treatment of shock: It has the best effect on infectious toxic shock. Followed by anaphylactic shock, also effective for cardiogenic shock and hypovolemic shock. 5.Hematological system diseases: It has good effect on acute lymphoblastic leukemia. It can also significantly relieve the remittance, granulocytopenia, thrombocytopenia, allergic purpura, etc., but it needs long-term high dose. 6, skin diseases: psoriasis, eczema, contact dermatitis, can be used topically, but for severe skin diseases such as aspergillosis and exfoliative dermatitis, systemic administration is required. 7. Malignant tumors: Malignant lymphoma, advanced breast cancer, prostate cancer, etc. are effective. 8. Acute lymphoblastic leukemia is one of the common leukemias A regimen consisting of glucocorticoids is a commonly used chemotherapy regimen in clinical practice, but it is controversial which glucocorticoid is best to apply. Some studies have concluded that the efficacy of dexamethasone is better than that of prednisone, because it can cross the blood-brain barrier to prevent the recurrence of leukemia in the central nervous system, and the duration of remission is prolonged in patients treated with it.