Women who take potassium permanganate sitz baths may experience injuries such as skin irritation signs localized to the urethra and vagina. Potassium permanganate, when appropriately diluted, can be used as an adjunctive treatment for localized infectious diseases of the skin. The use of potassium permanganate needs to be diluted and high concentration of the drug is prohibited. Due to the special physiological structure of women, there are openings of the urethra and vagina near the urogenital diaphragm, which are more sensitive to stimulation compared with men, and improper use may cause adverse reactions such as local burning and pain. When these adverse reactions occur, it is recommended to stop using the medication and rinse with water, and if the symptoms continue to be unrelieved, it is recommended to go to the hospital in time. It should be noted that if there is localized skin and mucous membrane damage, it is not recommended to use potassium permanganate for scrubbing or soaking. Potassium permanganate should be administered under the supervision of a clinician; potassium permanganate must be diluted before administration.