A nodule on the vulva may be a vulvar vestibular gland cyst, condyloma acuminatum, vulvar tumor, etc. It is necessary to go to the hospital for a gynecological examination, and if necessary, surgical treatment is needed, and pathology tests can be done to confirm the diagnosis. Vestibular cysts or abscesses, occurring on one side of the labia minora, are locally raised and accompanied by infection, which can be painful and may even cause purulent discharge. Condyloma acuminatum, which are scattered or clustered small pink or white papillary warts with sharp tips, which grow larger and fuse to form a cauliflower shape as the disease progresses. Vulvar tumors, vulvar fibromas, lipomas, smooth muscle tumors, etc. will be manifested as nodular protrusions, found fibromas or larger lipomas, need to be surgically removed. A nodule found on the vulva needs prompt medical attention.