When friends and family get together, fragrant elbow, rice flour meat, buckle meat on the table. When we face this greasy piece of fat meat, do we eat or not? Such a piece of fat meat after eating, in addition to gaining weight, but also on our cardiovascular effects? After eating fat meat, our blood fat will rise. Excessive blood lipids can change the composition and flow rate of blood, and produce a series of pathological changes on our cardiovascular system. First, high blood lipids can directly cause vascular endothelial cell dysfunction and increased permeability of vascular endothelial cells Lipid droplets entering the blood vessel wall will activate the monocyte/macrophage phagocytosis system, macrophages phagocytosis of lipid droplets, it will turn into a round, larger, transparent cells like foam, called foam cells. Macrophages can also attract monocytes inside the blood, so that monocytes accumulate here and stimulate the production of various growth factors and cytokines, which can further damage the vascular endothelial cells. Second, the vascular endothelial cells in the role of the above mechanisms, the structure and function of endothelial cells change The vascular endothelium from the beginning of the smooth, intact and become uneven, which will promote the increase in platelet adhesion, smooth muscle cell proliferation and secretion of matrix. Third, the role of inflammation This role throughout the whole process of the beginning of the lesion, progression and the formation of complications. Macrophages can produce a variety of biologically active substances, such as interleukin-1 and tumor necrosis factor. These substances further promote inflammation. Fourth, the endothelial morphology changes Due to the deep lipid stimulation, together with the platelets attached to the vascular endothelium, monocytes, etc. will promote smooth muscle cell proliferation, then the endothelium will be significantly thickened, hardened. The endothelium will thicken and harden. The morphology of the endothelium will then change. These are the causes of vascular lesions caused by hyperlipidemia, which are the basis of vascular lesions and can cause the following visible changes in blood vessels. 1. Lipid stripe formation In the arterial intima can be seen in the yellow cap pinhead large spots or stripes of different lengths, stripes about 1-2mm wide, flat or slightly elevated. Microscopically these can be found to be the product of a large number of foam cell aggregates. 2. Fibrous plaque: Irregularly elevated plaques scattered on the surface of intima. Initially yellow or gray-yellow, later due to the increase of collagen fibers in the surface layer of the plaque and vitreous change and become porcelain white, shaped like solidified candle oil. The plaques are of different sizes and can be combined. 3. Atheromatous plaques Gray-yellow plaques can be seen in the intima of blood vessels, which are both elevated to the surface and compressed to the depth. Incision reveals a yellow atheromatous material. Microscopically, cholesterol crystals and calcification are seen, surrounded by granulation tissue and inflammatory cells. 4. thrombosis Endothelial injury at the lesion exposes collagen fibers of the vessel wall, platelets aggregate locally and form thrombi, leading to ischemia and infarction. 5. other changes such as intraplaque hemorrhage, rupture and ulcer formation. Calcium salt deposition can make the blood vessel hard and brittle, easy to rupture. Aneurysm formation or resulting in entrapment aneurysm. It does seem that chronic hyperlipidemia can have an effect on the cardiovascular system. Today, we eat a piece of fatty meat, only a slight change will occur. However, with long-term dietary irrationality and lack of exercise, such changes may take place and may result in serious consequences such as coronary heart disease and cerebral hemorrhage. Therefore, we still need to start from the usual little by little, to develop good living habits, so that a healthy life will always be around us.