Arterial occlusion of the lower limbs caused by diabetes can be treated with medication to lower blood sugar, improve blood circulation, protect blood vessels, and surgery if necessary. Lower limb arterial occlusion in diabetic patients belongs to the complications of diabetes mellitus, which can be clinically manifested as numbness of the limbs, fatigue after activities, intermittent claudication and nocturnal rest pain and other symptoms. Drug treatment is based on lowering sugar, and under the premise of controlling blood sugar, applying drugs to improve blood circulation and protect blood vessels. If the effect of medication is not good, or the condition is serious, it needs to be treated by surgery, which can take methods such as vascular reconstruction or intervention. When diabetic patients have lower limb arterial occlusion, they should go to the hospital in time and be treated under the doctor’s advice.