Symptoms of Raynaud’s disease include intermittent vasospasm, pain and sensory abnormalities. The etiology of the disease is still unclear and may be related to sympathetic nerve dysfunction, vascular sensitivity factors, structural factors of the vascular wall, and genetic factors. 1.Symptoms (1) Intermittent vasospasm: during ischemic period when cold or emotionally agitated, the fingers and nose tip start to become pale and cold, and the skin temperature decreases; during hypoxic period, the extremities are bruised and the skin temperature decreases; during congestive period, the skin is flushed and the skin temperature rises, and then returns to normal. (2) Abnormal pain and sensation: in ischemic and hypoxic periods, numbness, ants sensation, pain, etc. may appear. 2. Etiology: the etiology is unclear and may be related to the following factors. (1) Sympathetic nerve dysfunction: when it is cold, the blood vessels of the extremities undergo spasm, resulting in local ischemia. (2) Vascular sensitivity factors: the sensitivity of extremity arteries to cold increases. (3) Structural factors of the vascular wall: changes in the organization and structure of the vascular wall can lead to vasoconstriction. (4) Genetic factors: some patients have family members with vasospasm. It is recommended that patients with Raynaud’s disease go to the hospital in time, and under the guidance of the doctor for standardized treatment.