Occasional use of Kefir in mid-pregnancy has no effect on the fetus, but it should not be used frequently. The main ingredient of Kesiclofenac is glycerin, and if constipation occurs in mid-pregnancy, you can use Kesiclofenac under the guidance of a doctor to stimulate the intestinal wall and cause an excretory response to help defecation. Kefir is a topical drug, absorption is relatively small, and will not pass through the placental barrier, the use of mid-pregnancy will not jeopardize the health and development of the fetus. However, if the frequent use of Kefir during pregnancy will jeopardize the health of the pregnant woman and the fetus, long-term use of Kefir may produce dependence, once the drug is discontinued, constipation symptoms are likely to worsen, severe constipation in the force of stool may stimulate the uterus to contract, increasing the incidence of preterm delivery in the middle and late pregnancy. Therefore, if constipation symptoms occur in mid-pregnancy, you can occasionally use Keflex, but should not be used frequently, pay attention to eat more vegetables and fruits, drink more water, appropriate activities to promote gastrointestinal motility can improve the symptoms of constipation.