With the industrialization of the world, the pollution of water and air, the living environment of human beings has deteriorated day by day. Toxic substances in the environment act on the human body, and the more sensitive reproductive system in the human body naturally suffers from them. Chemical toxic substances in the environment. Such as metal lead, cadmium, manganese, mercury, arsenic, etc. can directly or indirectly damage the function of the testicles. Next is pesticide. Not only damage the health of pesticide users, but also can make more people suffer from pesticide poisoning through polluted water, air, soil and agricultural by-products. Some common organic compounds in life. Such as food additives, food coloring agents can damage the spermatogenic function of the testes. In addition, some drugs have reproductive toxicity. Abuse of such drugs often impairs the function of the testes. Many physical factors in the environment can affect the reproductive function of the testes, the most common of which is heat. Heat can cause damage to the spermatogenic epithelium of the testes, with cells degenerating and falling off and spermatogenesis being impaired. In reality, the testes of workers who work under high temperature for long periods of time have impaired function and decreased semen quality due to the effects of heat, resulting in infertility. Since microwave and infrared rays can produce thermal effects, they can also produce similar destructive effects on the testicles as heat. Radiation can also damage the testes, reducing sperm and decreasing viability. Bad lifestyle affects the reproductive function of the testicles People who like to wear tight pants (such as jeans), because the scrotum does not easily dissipate heat, their testicles are easily affected by heat and their function is impaired, resulting in a decrease in semen quality. Bad habits such as smoking, drinking and drug use can affect male fertility. Long-term smokers have lower sperm density and vitality, and higher rates of deformed sperm. Alcohol abuse can lead to testicular spermatogenesis disorders and decreased semen quality. Certain life and leisure practices, such as sauna baths, increase the temperature of the scrotum and impair spermatogenesis in the testes, which can also lead to infertility. Medical factors affect the reproductive function of the testes Certain drugs. For example, anti-hypertensive drugs such as lisinopril and guanethidine, sedative drugs such as Valium and meprobamate can affect penile erection and reduce sexual function. Anticancer drugs, hormone drugs, cyclosporine drugs, etc. have reproductive toxicity, and abuse of such drugs often impairs the function of the testes, leading to infertility. Decrease in sperm count after one month of memantine. Disease factors. There are many of these diseases, such as cryptorchidism, varicocele, Crohn’s syndrome, pituitary tumors, etc. These factors affect the function of the testicular varicocele, so that sperm production is affected and leads to infertility. Others are: diabetes and neurological disease, chronic wasting disease (cirrhosis, renal failure)/tuberculosis/malnutrition, high fever in the last 6 months, history of surgery (urethral stricture surgery, superior/inferior urethral cleft surgery, infantile urethral valve surgery, prostate surgery, bladder neck surgery, sympathectomy N, larger retroperitoneal surgery, vasectomy, syringomyelia surgery, inguinal hernia repair) , sexually transmitted diseases (syphilis, gonorrhea, chlamydia, mycoplasma), prostatitis/ seminal vesiculitis/ epididymitis, prostate tuberculosis/ seminal vesicle tuberculosis/ epididymal tuberculosis, Gardnerella infection (circumcision, glansitis), orchitis (post-pubertal mumps, other orchitis), testicular injury, testicular torsion. Psychosocial factors affect the reproductive function of the testes Increased social and family burdens and complex interpersonal relationships. Intense anxiety can cause ovulation disorders and uterine contractions leading to miscarriage in women and abnormal spermatogenesis in men. To increase the chances of conception one should be aware of general knowledge about reproduction and should encourage people to make efforts to acquire scientific knowledge about reproduction. Some diseases that cause testicular dysfunction are treatable and these should be actively treated, and reducing one factor is one step closer to eventually gaining fertility. The factors that lead to infertility in life are variable, so one should try to avoid various risk factors that may lead to infertility.