If only anti-Sm antibodies are present, without any other uncomfortable manifestations and abnormal examination indicators, it is not possible to diagnose SLE, and it does not matter whether the disease is serious or not. The anti-Sm antibody is the hallmark antibody of SLE and has a high specificity of about 99%, but the anti-Sm antibody has a low sensitivity and the presence of this antibody does not correlate significantly with the activity of SLE. If only positive anti-Sm antibodies are found in the clinic, the possibility of SLE should be highly suspected, but whether a definite diagnosis can be made will have to be combined with clinical manifestations and other examination indexes to make a comprehensive judgment. Therefore, once a patient shows anti-Sm antibody positivity, it is necessary to consider the possibility of SLE, and also to consult a doctor as soon as possible to improve other related examinations to determine the presence of SLE as soon as possible, so that early treatment can be targeted.