After smoking for 40 to 50 years, sudden cessation of smoking may result in a withdrawal reaction. Cigarettes contain nicotine and other substances that make the human body dependent. Suddenly quitting smoking may produce a certain withdrawal reaction, which may be manifested as tightness in the chest, shortness of breath, poor quality of sleep, irritability, poor appetite, etc. The withdrawal reaction is usually alleviated and disappears after four to five months. Generally, it will gradually decrease and disappear after 1~3 months. Due to the long history of smoking, smoking cessation should be gradual. At the same time, life should be away from the smoking environment and people, usually eat more fresh vegetables and fruits, more physical exercise, keep a happy mood, slowly reduce the dependence on nicotine, to achieve the purpose of healthy smoking cessation. If you have been smoking for forty or fifty years and suddenly quit smoking, there may be withdrawal reactions, quitting smoking should be gradual, in the process of quitting smoking if there is discomfort, it is recommended to consult a doctor in a timely manner, under the guidance of the physician active treatment.