Epilepsy is a common chronic brain disease of the nervous system that has long relied primarily on antiepileptic drug therapy. With the shift in the modern medical paradigm, the role of psychosocial factors in the occurrence and development of epilepsy has received increasing attention. It is estimated that about 1/3 of patients with epilepsy present with psychiatric disorders and 3/4 have both psychiatric and psychological problems, and the role of psychosocial and epileptic psychological factors in the development of epilepsy has received increasing attention. Therefore, understanding the psycho-behavioral characteristics of epilepsy patients and combining psychotherapy with pharmacological and surgical treatment is important to effectively control seizures and improve the quality of life of patients. Patients with epilepsy may exhibit periodic mood changes such as anxiety, distress, nervousness, hostility, low self-esteem, and irritability.Baker et al. investigated more than 5000 cases of epilepsy patients, 48% of whom had anxiety and 51% felt embarrassment and shame. Depression is common in patients with epilepsy, and the severity of depression is related to the course of epilepsy. Foreign literature reports that suicide rates are five times higher in patients with epilepsy than in the general population, with temporal lobe epilepsy predominating. A study of 80 patients with epilepsy in two regions with a high prevalence of epilepsy by domestic experts showed that almost all patients had an affective adjustment disorder, 85% felt that their self-esteem was hurt, and 98% felt a sense of mental stress. Emotional disorders are a common psychological disorder in patients with epilepsy and are mainly caused by patients’ fear of seizures and side effects of AEDs and social stigma against epilepsy. Appropriate physical exercise can suppress the cerebral cortex, improve the psychological disorders and enhance the quality of life of patients with epilepsy. The intensity and modality of exercise should be individualized according to the triggers of seizures and the degree of control. Patients with frequent seizures and those who have had seizures during or after exercise should be treated with caution. Rehabilitation exercises should be offered to patients with motor impairment. The mechanism of seizure reduction by exercise may be related to increased monoamine metabolism and beta-endorphin release in the central nervous system, the latter of which may have anticonvulsant effects. A small number of seizures during exercise may be related to hypoglycemia, fever, some degree of hyperventilation, or stress leading to catecholamine release.