1. Treatment: Internal use of Ermiao pill: 9g/time, 2 times/day; safflower liver clearing 13 flavor pill: 13 capsules/time, 2 times/day. 2. Results: 39 cases were clinically cured, 29 cases showed efficacy, 3 cases were effective, and 1 case was invalid, with an overall efficiency of 94.4%. 3. Discussion: Ermiao Wan is composed of Atractylodes and Phellodendron, which is a famous formula for drying dampness and clearing heat, and is clinically used for damp-heat evidence, especially for those who have more dampness than heat. In order to strengthen the function of clearing heat toxins, the author combined with Safflower Liver Clearing Thirteen Flavor Pill, which is good at clearing heat toxins. Safflower Liver Clearing Thirteen Flavors Pill is a Mongolian medicine that has the function of clearing liver heat and detoxifying toxins. The drug consists of safflower, wood incense, neem, gardenia, sandalwood, musk, buffalo horn concentrated powder, niu huang, clove, etc. Among them, niu huang, buffalo horn, gardenia, etc. clear heat and detoxification, safflower, wood incense, clove, sandalwood, musk, etc. detoxify the liver and resolve stagnation. According to Chinese medicine, qi dissolves dampness, and a smooth flow of qi is conducive to dispelling dampness. The combination of the two prescriptions directly targets the pathogenesis of acute eczema, so the clinical effect is satisfactory. Clinical observation shows that Ermiao Wan combined with Safflower Qing Liver Thirteen Flavor Pill for the treatment of acute eczema is effective in terms of lesion area reduction, efficacy and therapeutic index, and is easy to apply with no significant side effects.