Highly differentiated squamous cell carcinoma of the tongue is a malignant tumor, which is more serious and may continue to progress. Once diagnosed, it needs to be treated actively, but the severity of the disease is related to the type of cancer and metastatic site. 1. Cancer type: tongue cancer mostly occurs at the edge of tongue. Then the tip of tongue, back of tongue and so on. The cancer grows fast and has strong infiltration, which can involve the tongue and cause tongue movement limitation. Ulcerative or infiltrative type is more malignant and serious. Advanced tongue cancer may spread to the floor of the mouth and the mandible. It causes inability to speak, eat and swallow. Backward development can invade palatoglossal arch and tonsils. 2. Metastatic site: tongue cancer is easy to be lymphatic metastasis in early stage. It can be transferred to lungs, which is more serious. Highly differentiated squamous cell carcinoma of tongue in middle and late stages needs radiotherapy and other treatments. Surgery is the mainstay, and the situation is more serious. When oral cancer occurs, you need to seek medical treatment as soon as possible to avoid complications.