Cleft lip and palate is a relatively common facial abnormality. 3-10 weeks of gestation is an important period of fetal facial development, which is susceptible to genetic, radiation and medications, resulting in poor lip development and cleft lip and palate. B-mode ultrasound diagnosis of cleft lip and palate is usually performed at 23-36 weeks, when the fetus has good mobility, a clearer face and a high detection rate. In addition, some fetuses can be detected with cleft lip and palate as early as 13-14 weeks of labor and delivery. Common causative factors for cleft lip and palate include genetic factors, pathogenic infections, chronic illnesses during pregnancy, as well as the use of stimulant medications during pregnancy, exposure to radiation, and folic acid deficiency. After the discovery of cleft lip and palate, there is usually no effective way to correct it during pregnancy. It is necessary to keep away from the causative factors, such as supplementation of trace elements, moving away from polluted environment, stop smoking and drinking, etc. It is also necessary to check the morphology and structural function of other organs to determine whether there is any malformation, and the pregnancy may need to be terminated if there are serious comorbidities. Simple cleft lip and palate can be corrected by surgery 3 months after the delivery of the fetus, and later facial plastic surgery can restore normal function and will not affect daily life.