First of all, it should be clear that renal puncture is not a disease, but a means of examination performed to clarify the diagnosis. Renal puncture pathological examination has become the gold standard for the diagnosis of kidney diseases. The main clinical significance of renal puncture pathological examination is as follows: first, to clarify the diagnosis; second, to guide the treatment, to clarify the pathological type through pathological analysis, and to formulate the corresponding treatment plan according to the pathological type; third, to assess the prognosis, renal puncture pathological examination can visually check the condition of the glomerulus, and to assess the prognosis of the patient according to the condition of the glomerulus. The prognosis of the patient can be assessed according to the glomerular condition. Therefore, the current proportion of kidney puncture is relatively high and it has become a very skillful operation skill, plus most of them are performed under B-ultrasound guidance, which greatly reduces the operation risk.