The drug treatment of duodenal ulcer includes anti-Helicobacter pylori treatment, inhibiting gastric acid secretion, protecting gastric mucosa, promoting gastrointestinal dynamics, etc. It is recommended to take oral medication under the guidance of a doctor. 1. Anti-Helicobacter pylori treatment: the common method is quadruple therapy, i.e., one proton pump inhibitor, two antibacterial drugs, one bismuth agent, commonly used drugs such as omeprazole, amoxicillin, clarithromycin, bismuth potassium citrate and so on. 2. Inhibit gastric acid secretion: commonly used drugs are proton pump inhibitors, such as omeprazole, rabeprazole; antihistamines, such as ranitidine, famotidine and so on. 3. Drugs to protect gastric mucosa: commonly used drugs are magnesium aluminum carbonate, aluminum thioglycollate and so on. 4. Gastrointestinal stimulants: commonly used drugs such as domperidone and mosapride. Duodenal ulcer patients should be used under the guidance of a doctor, do not apply on their own.