Usually, if the patient has uterine fibroids or ovarian cysts, it is necessary to decide whether the vaccine can be given according to the patient’s condition. The vaccine can be given during the stabilization period, but should not be given during the flare-up period and exacerbation of the disease, depending on the doctor’s advice. Uterine fibroids are the most common benign tumors in clinical medicine, while ovarian cysts are cystic masses on the patient’s ovaries. Contraindications to vaccination include allergies to vaccine components, acute illnesses, chronic illnesses, and fever. Uterine fibroids and ovarian cysts are not contraindications to the new crown vaccine and can usually be vaccinated. Patients with acute uterine fibroids or ovarian cysts that have ruptured or enlarged are not recommended to receive the vaccine if their condition is unstable. Patients should wait until their condition has stabilized before receiving the vaccine. If patients insist on receiving the vaccine, their condition may worsen. It is recommended that patients develop good dietary habits in their daily life, go to the hospital for regular checkups, and strengthen physical exercise, which is conducive to good health.