At present, with the improvement of living standard in China, the incidence of gallbladder stones is increasing year by year, and the current incidence rate is about 8-10%. Many patients suffering from gallbladder stones will ask themselves the causes of gallbladder stones in outpatient clinics. Since the causes of stones are complex and require quite a lot of words to describe and are highly specialized, here we will write down the high-risk factors that predispose us to gallbladder stones as a reminder. First, skipping breakfast is a strong predisposing factor. Gallbladder contraction and emptying is done by the action of cholecystokinin after eating, and after a night’s rest, not eating breakfast can lead to an excessive accumulation of bile. Women: The results of a large number of cases show that women have a greater chance of developing gallbladder stones than men, which is related to the role of estrogen and also closely related to women’s lifestyle habits. Obesity: Cholesterol metabolism disorder is the main factor. Over 40 years old, especially women over 40 years old. It is related to the decrease of estrogen level and metabolic changes. These are the factors related to susceptibility to gallbladder stones, but it is not certain that people who meet the above conditions will suffer from gallbladder stones. In conclusion, good lifestyle habits and regular physical examinations help to maintain a good quality of life for us.