Eosinophilic proliferative lymphogranuloma has a slow onset and long course. Symptoms of the disease mainly include the appearance of multiple painless soft tissue masses, enlarged lymph nodes, itchy skin and hyperpigmentation. In addition, the main complications of the disease are nephrotic syndrome and bronchial asthma.1. Multiple soft tissue lumps: the most common clinical manifestation of the disease, the lumps can appear at the same time or successively, 75% of them are located in the maxillofacial area, most of them are found in the peri-auricular area, parotid gland, submandibular area and cheeks etc., and sometimes it can also involve the lips, dorsum of the nose, vestibule of the nose, medial canthus, orbital, lacrimal glands, temporal area, back of occiput and palate, soft palate, nasopharynx and other parts of the body. Other parts of the body such as the back of the shoulder, breast, and chest wall may also be involved. The lumps are characterized by indistinct borders, painlessness, adhesion to the skin and poor mobility. The size of the lump is 1~10cm, and the lump can be more than 10cm, the texture of the lump is like soft rubber in the early stage, and it can be hardened with the growth of the disease until it is as hard as a tire, and it can also be shrunken and then grown, and it can be painful when it is complicated with infection. Lump growth is slow, can be many years without obvious changes; 2, lymph node enlargement: is a very common clinical manifestations, mostly seen in the chin, submandibular, neck of the superficial lymph nodes. Often more than one lymph node is involved, sometimes it can also involve the inguinal, axillary and pulmonary lymph nodes; 3, itchy skin and hyperpigmentation: the incidence of 40% to 100%, mostly occurring in the skin at the mass, there can be spotty rashes and oozing, and in severe cases, localized vesiculation, ulceration, and generalized itchy people.