There is a piece of hard skin on the lips like callus may be caused by chronic lipitis or discoid lupus erythematosus. 1. Chronic lipitis: the cause is unknown, mostly related to various chronic long-term persistent stimulation. Performance for the lips dry, burning or pain, lip swelling, congestion, lip red flaking, cracking, surface oozing crust. It is suggested that patients should remove the irritating factors and change the bad habits such as lip licking and lip biting. 2. Discoid lupus erythematosus: Discoid lupus erythematosus on the lips is manifested as a rose-red spot with a slightly concave center and slightly raised edges in the form of a disc. It can be expanded to the skin side, resulting in unclear boundaries of lip-red skin. The skin lesions may gradually change from peach color to brown color, and hyperpigmentation or depigmentation may occur. The lips are flaky and may have edematous erosions and crusting. Cause a piece of hard skin on the lips like a callus may also have other reasons, it is recommended that the patient promptly to the hospital, to clarify the cause of the disease, standardized treatment.