Liver insufficiency simply means that liver functions such as transaminases and bilirubin are abnormal. The main causes include physiologic factors and pathologic factors. 1. Physiological factors: Liver insufficiency caused by physiological factors is often transient and can be reversed after timely correction. Common physiological factors include: drinking alcohol, staying up late, irregular work and rest, emotional changes, obesity and so on. Normally, we should develop good living and dietary habits, actively participate in physical exercise, and maintain an optimistic mindset. 2. Pathological factors: mainly including infectious diseases, alcoholic hepatitis, drug liver injury, cirrhosis, hepatocellular carcinoma, autoimmune diseases, biliary tract diseases, etc. These diseases usually directly or indirectly cause the destruction of liver morphology and structure, damage to hepatocytes, resulting in metabolism, synthesis and secretion dysfunction of the liver, and the emergence of hepatic insufficiency. Liver insufficiency may also have other causes, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.