Knee pain may be related to arthritis, knee synovitis, joint cavity effusion, trauma and so on, need to combine with the cause of the disease to choose the right treatment for the cause. 1. Arthritis: it often shows joint pain, swelling, stiffness, limited movement, etc. It is recommended to give painkillers such as hydrocodone, non-steroidal anti-inflammatory drugs such as ibuprofen, naproxen, etc., anti-rheumatic drugs such as methotrexate, corticosteroids such as prednisolone, etc., and consider surgical treatments such as joint repair and joint replacement for those who have not had good results in the treatments or whose condition is serious. 2. Knee synovitis: often manifested by knee swelling, pain and activity limitation, etc. It is recommended to give anti-inflammatory and analgesic drugs such as gel paste. Non-steroidal anti-inflammatory drugs such as celecoxib, etoricoxib, etc.; anti-rheumatic drugs such as methotrexate, biological response modifiers, etc.; injection of drugs into the joint cavity, such as glucocorticosteroids, sodium vitrate and so on. Surgery should be considered if the treatment effect is unsatisfactory or the condition is serious. 3. Joint cavity effusion: it often shows joint swelling, pain, activity disorder, etc. First of all, proper rest should be given to reduce joint activities, and it is recommended to give antipyretic and analgesic drugs such as ibuprofen, aspirin, etc. and antibiotics such as vancomycin, etc. If the treatment is not effective or the condition is serious, surgery should be considered. If the treatment effect is unsatisfactory or the condition is serious, consider arthroplasty, lesion removal surgery and other treatments. In addition, common traumatic injuries can lead to the development of knee pain. If knee pain does not improve or worsens, or is accompanied by other symptoms, it is advisable to seek medical attention to avoid delaying treatment. Medications should be used under a doctor’s supervision.