Pain in the lower right corner of the stomach while running may be caused by physiological factors, or it may be a symptom of some diseases, such as appendicitis, intestinal cramps, urinary stones and so on. 1. Physiological factors: If you do not usually have physical exercise, and suddenly perform high-intensity exercise, such as running, your body is in a high load state, which may lead to insufficient blood supply in the abdominal cavity, thus causing pain and other symptoms in the lower right abdomen, and in severe cases, it may lead to abdominal muscle strain, which may also cause similar symptoms. 2. Pathological factors: the main clinical manifestation of appendicitis patients is metastatic lower right abdominal pain, strenuous exercise can induce the occurrence of the disease. Running, catching cold and other factors can lead to gastrointestinal spasms, and patients can manifest abdominal pain. During running, the patient’s urinary stones move down the ureter to stimulate the ureter, thus causing abdominal pain. When patients experience pain in the lower right corner of the stomach while running, they should immediately go to the hospital for a clear diagnosis and symptomatic treatment.