Low-protein diet is to limit protein intake can improve the progress of renal function in patients with chronic kidney disease, but the incidence of malnutrition in chronic kidney patients is still high (about 30%-60%), and malnutrition is one of the important factors affecting the quality of life, the incidence of complications and survival rate. A reasonable low-protein diet can prevent and control the occurrence of malnutrition. Patients on a long-term low-protein diet need to pay attention to the following matters: ① timely examination and assessment of nutritional status; and take effective measures to actively adjust; ② ensure the daily caloric supply of 30-35 kcal per kg of body weight; ③ generally need to ensure daily protein intake of 0.6 g per kg of body weight, below this limit should be added with essential amino acids or α-keto acids; ④ low-protein diet needs to have more than 50% of (4) More than 50% of the protein in a low-protein diet should come from high-quality protein; (5) Maintain a reasonable ratio of protein, sugar and fat in the diet; (6) Pay attention to the supplementation of vitamins, fiber and minerals.