Cranial defects are often associated with headache, local tenderness, irritability, restlessness, etc.; or fear of local collapse and pulsation. As a large skull defect causes serious deformation of the patient’s head, it directly affects the physiological balance of intracranial pressure, and because the atmospheric pressure acts directly on the brain tissue through the defect area, it will inevitably lead to local brain atrophy and aggravate the symptoms of brain wasting after a certain period of time. Therefore, patients with cranial damage should receive timely repair surgery. In fact, the difficulty of skull repair surgery is not very big, the most important thing is the choice of material. However, the peek material that we use now is close to autologous bone in terms of hardness and adaptability. The material is a new type of polyether ether ketone PEEK bionic material, the mechanical and thermal properties of the material is very superior, and has a high degree of biocompatibility, can perfectly achieve the cranial bone symbiosis, is currently suitable, safe and effective cranial bone repair material.