The total cumulative dose of cyclophosphamide applied to patients with nephrotic syndrome is approximately 8 grams, which would require 8 applications if 1 gram is applied monthly. Nephrotic syndrome is considered to be an immune-related disease, therefore, hormones are usually applied for the treatment of this disease. However, some nephrotic syndromes are not very effective after hormonal treatment, and cyclophosphamide is also applied. The cumulative dosage of cyclophosphamide is 8 grams, and there are two main uses: the first use is to apply 1 gram per month, and the number of times used is 8. The second use is 0.1 grams orally per day, 80 times, with the first use being the most common. If you have nephrotic syndrome and need to use cyclophosphamide, it is recommended to decide the usage under the guidance of the attending physician and avoid self-application because cyclophosphamide has many side effects, some of which are serious, so it is important to review liver function, kidney function and blood count every month during the application process.