Seizures can be controlled in 70-80% of patients with epilepsy after drug treatment, and more than 60% of these patients remain seizure-free after withdrawal of medication. However, in about 30% of patients, seizures may recur within 2 years of starting a medication reduction, with the majority of seizures occurring within the first 9 months of starting a medication reduction. 1. Patients who have been completely seizure-free for more than 2 years on medication may be considered for initiation of medication reduction. 2. Patients who have been seizure-free for a longer period of time are still at risk of having another seizure after stopping the medication and should be evaluated for the possibility of another seizure before deciding whether to stop the medication. 3. Patients with consistently abnormal EEG, multiple seizure types, significant neuroimaging abnormalities and neurological deficits have a significantly higher recurrence rate and should be on extended medication or long-term medication. 4. After treatment of the primary cause of secondary epilepsy, drug discontinuation can be started if there are no seizures for six months to one year. 5. Different syndromes have different prognosis, which directly affects the long-term remission rate after drug discontinuation. For example, in benign epilepsy syndromes in children, 1-2 years without seizures can be considered for drug discontinuation; in juvenile myoclonic epilepsy, even after 5 years without seizures, the recurrence rate after drug discontinuation is high; Lennox-Gastaut syndrome may require longer treatment time. 6. The discontinuation process should be done slowly and may last for several months or even more than 1 year. Each drug should be reduced by one-quarter of the dose at a time for at least one week before tapering. 7. In patients treated with a combination of multiple drugs, only one drug should be reduced at a time, and after withdrawal of one drug, at least 1 month should elapse before withdrawing the second drug if there is still no seizure. 8. If a seizure occurs during withdrawal, the withdrawal should be stopped and the drug dose should be restored to the dose before the seizure.