In order to relieve the patient’s knee pain, different methods should be used according to different causes, the specific causes are physiological, knee dislocation, fracture. The specific methods are physical therapy, drug therapy, surgical treatment of these three. 1. Physiological pain: If there is no obvious trauma history of knee pain, it is recommended to reduce the knee activity properly after the pain occurs to avoid the increase of knee injury. Appropriate rest can relieve knee pain to a certain extent, but also hot compresses and physical therapy to accelerate the recovery of the knee, effectively improve blood circulation in the knee, promote its metabolism and reduce pain. 2. Knee dislocation: For the pain caused by knee dislocation, common surgical methods include manipulation under anesthesia, incision and reset, knee arthroplasty and so on. It can relieve knee pain. 3. Fracture: knee pain may be a fracture, patients can take non-steroidal anti-inflammatory drugs such as ibuprofen and other analgesic anti-inflammatory; if the pain is too strong, oral opioid narcotic analgesic can also be effective in relieving the patient’s pain. And internal and external fixation surgery is performed to relieve pain. Therefore, it is recommended that patients with knee pain whose onset is non-physiologic pain should seek medical examination and take effective treatment according to the specific examination.