Glutaminase 45 is not necessarily a liver disease. Glutaminase is widely found in all cells and tissues of the human body, mainly in cells and tissues such as liver cells and heart muscle. The normal reference value of alanine aminotransferase is 0-40U/L. An increase of alanine aminotransferase to 45U/L may be caused by physiological factors such as late night, exertion, strenuous exercise, etc., or by liver diseases such as hepatitis, malnutrition, alcoholism, cardiomyopathy, cerebrovascular disease, skeletal muscle disease, etc., and it may also be related to chlorpromazine, isoniazid, quinine, salicylic acid preparations, ampicillin, carbon tetrachloride, organophosphorus and other Drugs and poisons. The concentration of ghrelin in hepatocytes is 1000-3000 times higher than that of serum, and as long as 1% of hepatocytes are necrotic, the enzyme activity in serum can be increased by 1 times, and in the acute stage of various viral hepatitis and drug-intoxicating hepatocellular necrosis, a large amount of ghrelin will be released into the bloodstream, therefore, ghrelin is an important indicator of viral hepatitis and toxic hepatitis. In summary, hepatocellular injury can lead to elevated alanine aminotransferase, but the cause of elevated alanine aminotransferase is not necessarily liver disease.