Coughs are commonplace, and almost everyone, young and old, has had a cough. People cough when they catch a cold or choke on a drink of water, but some people suffer from coughs for months at a time. Some patients even break their ribs and cough until they faint and become unconscious. What is it that makes a cough so pestering? And some coughs don’t matter whether they see a Chinese doctor or a Western doctor, whether they take dietary supplements or prescriptions, they just keep coughing, coughing, coughing, and coughing endlessly! One wonders if some coughs are really that difficult to treat. To solve the mystery of chronic cough, we must first find the cause of the cough. Chronic cough involves a variety of causes, not only related to the respiratory system, but also to the nasopharynx and the digestive system. Studies have shown that the common causes of chronic cough are postnasal drip syndrome, cough variant asthma, and gastroesophageal reflux, with gastroesophageal reflux causing a significant proportion of chronic coughs, as high as 20% to 40%. Gastroesophageal reflux cough is defined as a gastroesophageal reflux disease in which acid and other gastric contents reflux into the esophagus resulting in a cough as the main manifestation. Some patients with GERD cough have symptoms such as acidity, heartburn, and chest pain, but many patients have no reflux symptoms or feeding-related symptoms at all, and cough is their only manifestation. Therefore, in patients with chronic cough without esophageal reflux symptoms, the possibility of gastroesophageal reflux cough cannot be excluded. 24-hour esophageal PH monitoring is currently the most effective method for diagnosing GERD cough, but it does not diagnose non-acidic GERD. Confirmation of the diagnosis of non-acidic reflux or biliary reflux also relies on bile reflux monitoring and intraesophageal luminal impedance testing methods. For patients with chronic cough in units without esophageal PH monitoring or with limited financial resources, it is recommended that diagnostic drug therapy be considered for those with the following indications, i.e., a diagnosis of gastroesophageal reflux cough can be made if the cough disappears or is significantly relieved after treatment 1. There is a significant feeding-related cough, such as postprandial cough and feeding cough; 2. It is often accompanied by gastroesophageal reflux symptoms, such as acid reflux, heartburn and chest pain; 3. Other diseases are ruled out, or those treated as such are ineffective.