The biggest advantage of laser treatment for nevus of Ota is that it can selectively eliminate the lesions without affecting the normal tissues, so the treatment is very safe and will not leave scars or affect the physiological functions of the normal body after treatment. Nevus of Ota is a bluish-brown patchy lesion on the facial skin, which was first reported by Ota’s in Japan in 1938, hence the name. It occurs mostly in Asian people of color, and the incidence rate in China is about 16 per 1,000, and it is more common in women. It is a greenish-gray patch that develops within 20 years of age and shows that melanocytes that should be distributed in the basal layer of epidermis are lost in the dermis or subcutaneous tissue, forming unsightly pigmented spots. Although the lesion of nevus of Ota is widespread, it is a benign lesion and generally has no effect on physical health. However, because it is located in a prominent location on the face, it has a great impact on the image, so patients seek treatment by all means. Dermatology used to treat it with freezing, peeling and herbal medicine, but the results were not good. Plastic surgery uses surgical excision and suture, which is still effective for smaller nevus of Ota, but also leaves scar; larger nevus of Ota needs skin implant or flap repair, not to mention the unsightly scar in the donor area, and the face will also leave obvious traces after repair; until the introduction of laser technology, it brings hope to the treatment of nevus of Ota. Laser treatment for nevus of Ota is to apply the selective photothermal effect of light on objects of different colors, and apply laser of different wavelengths to selectively act on melanocytes in the dermis to make them heated and destroyed, while other tissues of the skin are not damaged, so that melanin can be removed.