Exhaustion and inability to eat does not usually lead to TB resistance, but may slow recovery from the disease. Tuberculosis is a chronic infectious disease caused by infection with Mycobacterium tuberculosis, for which prolonged anti-tuberculosis treatment is required. Some patients may become resistant to TB for a variety of reasons and have poor control of their disease. People who are tired and unable to eat may suffer from low immunity, which affects the efficacy of anti-tuberculosis drugs (e.g., entecavir, etc.), and thus may delay the recovery of the disease, but does not usually cause drug resistance. For unauthorized discontinuation of anti-tuberculosis drugs and irregular intake of anti-tuberculosis drugs, it may lead to the emergence of drug resistance. During the period of anti-tuberculosis treatment, it is necessary to go to the hospital for regular check-ups to clarify the changes of the disease so that the drugs can be adjusted in time under the guidance of the doctor.