In the second half of the night there is a strong feeling of hunger, clinically the first thing to look at is whether the patient has any pathology. Because the clinical situation leading to hunger, the common cause is endocrine system diseases, such as the most common diabetes or hyperthyroidism and so on can cause. There are other diseases, such as some patients with long-term hunger or poor diet at night, can cause a similar situation, mainly diabetes and hyperthyroidism is more common. Clinically, it must be combined with the patient’s other symptoms, such as whether there is usually more food, drink, urination, weight loss, frequent hunger, if so, consider the possibility of diabetes mellitus. If the patient has thinness, temper, protruding eyes, love sweating, love diarrhea, heart rate increase and so on, clinical should consider whether it can be caused by hyperthyroidism, it is best to check the relevant indicators to see if there is any problem. It is also important to consider whether the patient has other symptoms, such as abdominal symptoms, nausea, vomiting, stomach pain, fever, except for other causes of hunger.