Omeprazole does not aggravate appendicitis, but there is no therapeutic effect of taking omeprazole for appendicitis. Appendicitis is a lesion of congestion, edema, and necrosis that occurs in the appendix as a result of blockage of the lumen of the appendix, bacterial infections such as Escherichia coli and anaerobic bacteria, and other causes. Appendicitis may present with fever, metastatic metastatic right lower abdominal pain, nausea, constipation, and diarrhea. Omeprazole is a drug that inhibits gastric acid secretion and can be used in the treatment of gastric ulcers, duodenal ulcers, reflux esophagitis and other diseases caused by increased gastric acid secretion, but has no role in the treatment of infections such as Escherichia coli anaerobic bacteria, so patients with appendicitis are not recommended to take omeprazole. Ceftriaxone sodium, metronidazole, clindamycin and other drugs can be used for treatment, but it is not recommended for patients with a history of allergy, severe impairment of liver and kidney function. Patients with appendicitis are not recommended to take medication on their own, and it is recommended that they be treated with medication under the guidance of a doctor.