The formation of kidney stones is related to local factors such as metabolic abnormalities, drugs, urinary tract obstruction and infection. 1. Abnormal metabolism: because urine contains uric acid, oxalic acid, calcium acid, cystine and other components, when there is a physiological disorder, it is easy to promote the generation and growth of stones, mainly related to the inhibition of the formation of urinary crystals and aggregation of substances to reduce the decrease in urinary volume. 2. Drugs: if the long-term application of amphotericin, sulfonamides, acetazolamide, glucocorticoids and other drugs, to a certain extent, also prone to stone formation. 3. Local factors: it is mainly related to urinary tract obstruction, infection and the presence of foreign bodies in the urinary tract, which may be caused by renal calyceal neck stenosis, bladder neck stenosis, neurogenic bladder dysfunction and so on. Generally, it can be cured in time with standardized treatment and has a good prognosis. Patients should go to the hospital in time and cooperate with doctors for treatment.