Lipoma hurts when it is pressed, which may be caused by compression of peripheral nerve tissues, infection, vascular obstruction and so on. 1. Compression of peripheral nerve tissue, lipoma is one of the common benign tumors of soft tissue, the etiology is not clear, it may be related to local inflammation, systemic lipid metabolism abnormality, etc. It will appear as subcutaneous mass, mostly in the neck, shoulder, abdomen, etc. With the growth of the tumor, it can compress the peripheral tissues, affecting the nerves, which may cause pain in the local area. 2. Existence of infection, after the infection of lipoma occurs, the pressure can cause pain, which can be accompanied by pus and exudate outflow. 3. Obstruction of blood vessels, lipoma occurring in blood vessels, usually accompanied by pain, which can be aggravated by pressure. There is no clear drug treatment for the time being, mostly choose surgical treatment, lipoma excision, and pay attention to preventing wound infection after operation, whether there is pus and oozing.