Coronal fissures usually lead to a decrease in the resistance of the skin’s mucous membranes, which can lead to inflammation. Coronal fissures can be treated with antibiotics, both oral antibiotics and applied antibiotics. If a coronal fissure occurs, the first thing to do is to disinfect the entire penis, including the entire glans and foreskin, with iodine, and after disinfecting, you can apply some ointment, such as erythromycin ointment, fusidic acid ointment, etc., which usually improves after 1-2 weeks of using the medication. If the applied medication is not effective, you can add oral medication, such as cephalosporin antibiotic cefuroxime or macrolides such as azithromycin. The infection can be controlled more effectively. It is recommended that patients should seek early medical treatment if they have a coronal fissure, and the above drugs are not recommended for patients to buy and take on their own, so as to avoid serious adverse consequences.