Esophageal reflux after gastrointestinal anastomosis surgery can be improved by lifestyle modification and medication, and the treatment needs to be carried out according to the doctor’s prescription. 1. Lifestyle adjustment: It is recommended that patients avoid overeating, acidic and spicy food, and eat a light diet, as well as abstaining from smoking and alcohol, regular work and rest, and proper exercise. If necessary, the head of the bed should be elevated when resting. 2. Drug therapy: patients can take proton pump inhibitors such as rabeprazole, omeprazole and other drugs to inhibit the secretion of gastric acid and improve gastroesophageal reflux; you can also take drugs to protect the gastric mucosa, such as aluminum thioglycollate, and promote gastrointestinal peristalsis, such as mosapride, etc. to improve the symptoms. Drugs need to be under the guidance of the doctor combined with their own situation to choose the most suitable for their own, there are adverse reactions to the emergence of timely consultation, drug allergy is prohibited to use. After actively cooperating with the doctor to carry out standardized treatment, can significantly improve the prognosis of the disease, reduce the patient’s discomfort.