The following side effects will occur during radiotherapy for esophageal cancer patients: 1. Systemic radiotherapy reaction: patients will experience weakness and loss of appetite when they have been treated with radiotherapy for about 10 times. If chemotherapy is administered at the same time, nausea and vomiting may occur. At this time, symptomatic treatment measures can be taken, such as giving anti-emetic and appetite increasing drugs; 2. Radioactive esophagitis: when radiotherapy is administered for 10-20 times, patients will have painful swallowing or difficulty in swallowing and acid reflux, at this time, if the patient is mild, no treatment is needed. If the condition is serious and the patient is in pain, pain management or hormone treatment can be given to reduce swelling; 3. Lung and airway damage: the patient will cough up blood and irritating dry cough at this time, no treatment is needed. When the patient’s tumor is larger, the target area is larger during radiotherapy, the patient may have some serious radiotherapy reactions, the most serious is esophagotracheal fistula, that is, the tumor invades the trachea and the esophagus and trachea are connected, the patient will have coughing and choking sensation, if not found in time, the patient may cause aspiration pneumonia. The side effects of late radiotherapy occur 6 months after the end of radiotherapy, usually pulmonary fibrosis, and pulmonary fibrosis does not need to be dealt with if it is not too serious; 4. Esophageal stricture: it can be dealt with according to the patient’s condition, and if the patient’s stricture is more serious, stent placement can be considered.