There is no specific best treatment for acne, and the appropriate treatment should be chosen based on the severity of the acne. Patients with mild acne are treated with topical medications, while patients with moderate to severe acne require a combination of medications and physical therapy. 1. Mild acne patients can take topical antibacterial drugs such as clindamycin and benzoyl peroxide to kill Propionibacterium acnes and to provide anti-inflammatory treatment. Retinoids such as retinoic acid ointment can also be used to improve follicular sebaceous gland duct keratinization, dissolve acne, and can improve and prevent post-acne scarring and hyperpigmentation. 2. The treatment of patients with moderate to severe acne often requires a combination of methods in order to achieve the goal of healing as soon as possible. In addition to the topical medications mentioned above, oral antibiotics and retinoids can be used. Oral spironolactone and anti-androgens can also be used, and if necessary, cystectomy and drainage can be used to remove the acne. Physical therapy such as photodynamic therapy and laser therapy can also be used for those who do not tolerate the above treatments. Acne patients need to pay attention to adjusting their dietary habits and daily routine, maintain a good mood in order to cure acne as soon as possible, the drugs mentioned in the article need to be used under the guidance of a doctor.