There is no such thing as the best treatment ointment for severe acne. Severe acne usually manifests itself as nodules or cysts, and its treatment is mostly based on oral medication, which can be supplemented by physical therapy and other ways of improvement. 1. Medication: For acne patients with nodules or cysts, antibiotics such as amoxicillin and erythromycin should be taken orally to help reduce inflammation and sterilization. Oral isotretinoin can also be taken to facilitate the inhibition of Propionibacterium acnes and play an anti-inflammatory and bactericidal role. You can also use topical retinoids such as adapalene gel and retinoid cream, and antibiotics such as fusidic acid and mupirocin ointment. 2. Physical therapy: patients can also combine photodynamic, red and blue light irradiation to achieve anti-inflammatory, sterilization and other effects. There is no single way to improve severe acne, so patients are advised to go to a regular hospital and cooperate with the doctor for standardized treatment. The medication should be used according to the doctor’s prescription.