Enemas are used as a method of treating diseases with certain risks. An enema is a certain amount of solution that is passed through the anal canal and instilled into the colon through the rectum from the anus to help the patient defecate and pass gas. It can also be used to determine the diagnosis and carry out treatment with the input of drugs. Injuries to the intestinal tract, such as perforation and bleeding, can occur if the enema is not administered carefully, and children are at greater risk of this because of the weaker intestinal wall. Why are enemas less commonly used than oral and injectable drug delivery? (1) There is no additional cost for oral administration, and it is usually absorbed more quickly and to a greater extent than rectal administration. Injectable administration is faster and the drug is not destroyed by digestion in the gastrointestinal tract, and the dosage can be very precise, but it is mainly used in acute patients or in situations where there is no alternative. (2) There are problems such as easy leakage of drugs, small absorption area, irregular absorption, not easy to control the dosage, etc. Some drug stimulation may also cause local ulcers, and if the tube is inserted into the enema may also cause intestinal damage, leading to perforation and other risks. (3) Unless the suppository is specifically designed for rectal administration, or the drug instructions indicate that the drug can be administered by enema can be used.