Gliclazide extended-release tablets can increase body weight. Gliclazide extended-release tablets are oral hypoglycemic drugs commonly used in clinical practice and belong to the sulfonylurea class of hypoglycemic drugs. The mechanism of action of sulfonylurea hypoglycemic drugs is to promote insulin secretion by binding to the sulfonylurea receptors on the pancreatic β-cell membrane to exert hypoglycemic effects. Weight gain, so sulfonylurea hypoglycemic drugs, including gliclazide extended-release tablets, are able to cause weight gain in patients. Therefore, the following points should be noted when using Gliclazide extended-release tablets: 1. Adhere to diabetic diet and exercise therapy to reduce total calorie intake in food on the one hand and increase total calorie consumption on the other hand, which is conducive to weight control in diabetic patients. 2. Reduce the dose of sulfonylureas as much as possible under the premise of ensuring blood glucose control. 3. If patients can tolerate it, they can use a combination of biguanide agents, Glucosidase inhibitors and other glucose-lowering drugs with different mechanisms of action to reduce the effect of sulfonylurea glucose-lowering drugs on body weight.