Nourishing blood and brain particles and tianma wake up the brain capsule can treat headache. However, their composition, efficacy and main treatment are quite different, and do not belong to the same kind of medicine. Nourishing blood and clearing the brain granules is composed of angelica, chuanxiong, white peony, ripe rhizome, hook vine, chicken blood vine, Xiaku Cao, cassia seeds, mother of pearl, Yanhuisuo, fine Xin, with the efficacy of nourishing the blood and calming the liver, activating the blood and clearing up the channels and collaterals, and is used for the headache caused by the deficiency of the liver and hyperactivity of the blood, vertigo, dizziness, irritability, insomnia and dreaminess. The adverse reactions of the drug are rash, itching, nausea, vomiting, abdominal distension, diarrhea, abdominal pain. Note that pregnant women, allergic persons, patients with hepatic dysfunction are prohibited. Tianma Wake-up Capsule is composed of Tianma, Dilong, Calamus, Yuanzhi, Radix Rehmanniae Praeparata, Cistanches, with the efficacy of nourishing the liver and kidneys, clearing collaterals and relieving pain, it is used for headache and dizziness caused by insufficiency of the liver and kidneys, loss of memory, insomnia, slow reaction, tinnitus, lumbago, etc. The adverse reactions of this drug are unclear. The adverse effects of the drug are not clear. It is contraindicated in children, pregnant women and lactating women. If there is a need for medication, it is recommended to use it under the guidance of a professional physician to identify the evidence, and not blindly self-medication.