The role of the skull is irreplaceable, it is the protective barrier of the brain, if the skull is unfortunately damaged, the impact will be great. The incidence of cranial defects is very high in clinical practice, for example, some mechanical injuries, traffic accidents and falling objects may hurt the skull, so we must pay attention to it. Cranial defect is related to life safety, because when the skull is damaged, the intracranial environment and intracranial pressure will change accordingly, and the patient’s cerebrospinal fluid circulation and blood circulation will be involved, and it will also affect the neurological function, resulting in a series of cranial defect syndromes, for example, the patient will have a headache and dizziness, and his or her temper will become very violent, and it may be combined with vision disorders and epilepsy, and so on. Cranial defects should be actively dealt with, and cranial repair surgery is a good solution, which is a routine surgery without much risk, so patients do not have to worry too much. However, the material of skull repair and the doctor’s technical experience are very important, good materials for better recovery after surgery, the effect is also better to look at. At present, many places use more titanium mesh material, which is a metal material, compared with those materials in the past has a lot of progress, but also inevitably have some problems, such as easy to occur after the operation of hot and cold sensitivity reaction, the collapse of deformation, affecting the postoperative medical examination, and even there is a risk of exposure of the material. Following the titanium mesh material, we now apply a new type of polyether ether ketone peek material to comprehensively carry out the peek cranial bone repair and plastic surgery, and achieved good clinical results. peek material is a very safe polymer material, it makes up for the defects of titanium mesh material, all the properties and limb cranial bone match, and the effect of the postoperative natural and beautiful.