Taking osteopontinol at bedtime will reduce the occurrence of hypercalcemia.1. Because if oral calcium intake is higher during the day, people can take large doses of calcium from food at three meals, and if osteopontinol is taken orally at the same time as calcium intake is higher, the chances of hypercalcemia will increase. The intake of calcium at night before going to bed is relatively low, and there is also loss at night, in this case oral osteopontinol, will reduce the occurrence of hypercalcemia. 2, and the body’s metabolism. If taken orally at bedtime, osteopontin triol can well inhibit the secretion of parathyroid glands in the treatment of patients with chronic renal failure. Long-term bedtime oral administration can treat hyperthyroidism secondary to chronic renal failure. However, if it is for the treatment of common osteoporosis, it can be taken twice in the morning and in the evening without the need for long-term oral administration. But for patients with renal failure, or chronic renal bone disease, it is best to just take it at bedtime.